The Agilent LC-MS single quadrupole

The Agilent 1100 Series LC/MSD is a bench-top mass selective detector providing atmospheric pressure ionization of liquid samples. A wide variety of compound classes can be analysed using either electrospray (API-ES) or atmospheric pressure chemical ionization (APCI). Molecular weight information as well as structural information through collision-induced-dissociation (CID) provides useful qualitative sample data. Quantification is possible even in the presence of complex matrices in the selected-ion-monitoring mode (SIM).
The LC/MSD is easily interfaced to an HPLC system. Samples can be introduced after separation on a variety of columns from 1.0 to 7.5 mm using a range of mobile phases.
Mass spectral data provides the molecular weight and structural information. With both electrospray and APCI in positive or negative modes available, a wide range of samples can be analysed.  Molecular weight information is possible for both small and large molecules, up to 100,000 Daltons.

LC 1100

If you are interested in a metabolomic approach, the single quadrupole detector is an excellent way to increase the richness of your data set. Alternatively if you are profiling a smaller range of chemicals, it can distinguish between things that might otherwise be hard to separate chromatographically, and can confirm the purity of your HPLC peak. In single-ion-monitoring mode, it is also very sensitive.


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